Three polymorphisms in the 3′ UTR of the TRAIL (TNF-related apoptosis-inducing ligand) gene

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Periplasmic Expression of TNF Related Apoptosis Inducing Ligand (TRAIL) in E.coli

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of TNF family, is an interesting ligand which selectively induces apoptosis in tumor cells and, therefore, it has been developed for cancer therapy. This ligand has been produced by various hosts such as E.coli. However, protein expression in E.coli cytoplasm leads to problems such as incorrect folding, reduction in biolo...

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Periplasmic Expression of TNF Related Apoptosis Inducing Ligand (TRAIL) in E.coli

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of TNF family, is an interesting ligand which selectively induces apoptosis in tumor cells and, therefore, it has been developed for cancer therapy. This ligand has been produced by various hosts such as E.coli. However, protein expression in E.coli cytoplasm leads to problems such as incorrect folding, reduction in biolo...

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periplasmic expression of tnf related apoptosis inducing ligand (trail) in e.coli

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ژورنال

عنوان ژورنال: Genes & Immunity

سال: 2001

ISSN: 1466-4879,1476-5470

DOI: 10.1038/sj.gene.6363806